This electric sensor contains an array of gold biosensors integrated into the well plate, allowing real-time impedance detection to track and quantify the living cell adhesion-related dynamics. To date, the leading label-free sensing technology in the market is electric impedance sensing-based microelectronic sensors.
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It allows the targeted samples to retain their intrinsic states, minimising the side effects on the native conformation and biological activity of the targeted ligands, cells, or tissues. The team has filed for a US provisional patent.Ĭompared with conventional fluorescence molecules and radionuclide-based labeling techniques, label-free analysis enables biosignals changes to be monitored in real-time without artificial manipulation of individual samples. This practical device would provide new insights into the fundamental research of cell biology and drug discovery and assist in the development of a new generation of biosensors.
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However, existing approaches are often hindered by their multiple time-consuming preparation steps, complicated apparatus, and incompatibility which may interfere with the cells and cause unwanted influence on them.Īn interdisciplinary research team led by Dr Zhiqin Chu of the Department of Electrical and Electronic Engineering of the University of Hong Kong (HKU) and Dr Yuan Lin of the Department of Mechanical Engineering, HKU, in collaboration with Dr Kwai Hei Li from Southern University of Science and Technology, has developed a low-cost, highly miniaturized and incubator compatible GaN chipscope, which enables real-time monitoring of cells in the limited and humid space of an incubator.
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Label-free, non-invasive, and quantitative monitoring of cellular activities is crucial for understanding various biological processes and the response of cells to therapeutic drugs.